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</html>";s:4:"text";s:20094:"Background: The potential carcinogenicity of naphthalene (NA), a ubiquitous environmental pollutant, in human respiratory tract is a subject of intense debate. Groups of male and female albino CD-1 mice (approximately 6 weeks old at the start) were administered gavage doses of 0, 5.3, 53, or 133 mg/kg naphthalene (99.3% pure) in corn oil Canadians' exposure to naphthalene is attributed predominantly to indoor air, because indoor air levels generally exceed ambient air levels, and because of the greater time spent indoors. Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. fNaphthalene may damage the liver and kidneys. Exposure to large amounts of naphthalene may damage or destroy some of your red blood cells. Basis for original (SCP) IDLH: No useful data on acute inhalation toxicity are available on which to base the IDLH for naphthalene. It can also cause nausea, vomiting, abdominal pain, seizures and coma. increase in severity with increasing exposure duration and most effects were observed within a shorter duration Critical effect(s): Decrease in terminal body weight  Developmental Toxicity of Naphthalene (CAS No. f High exposure to Naphthalene can cause headache, fatigue, confusion, tremor, nausea and vomiting. Naphthalene exposure is a common cause of toxicity in older children, but is rarely described in neonates. (1984) Naphthalene toxicity in CD-1 mice: general toxicology and immunotoxicology. It is used as the starting material for the synthesis of other compounds, as a moth repellent, soil fumigant and lavatory deodorant. Chronic naphthalene poisoning through inhalation may produce a sequence of minor but . The amount necessary to produce lethargy or seizures is not known but may be as little as 12 g. Several infants developed serious poisoning from clothes and bedding that had been stored in naphthalene mothballs. Naphthalene poisoning is a rare form of toxicity that may occur after ingestion, inhalation, or dermal exposure to naphthalene-containing compounds such as mothballs. As an aromatic hydrocarbon, naphthalene's structure consists of a fused pair of benzene rings. Chronic Health Effects The following chronic (long-term) health effects can occur at some time after exposure to Naphthalene and can last for months or years: The substance is banned due to its toxicity to humans, especially children, and its carcinogenic (cancer causing) properties. Acute oral toxicity (LD50): 490 mg/kg [Rat]. Acute exposure to naphthalene by inhalation, in-gestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. (1963) found toxicity in newborn infants when the only exposure was to naphthalene vapor from clothes or blankets treated with naphthalene stored in the infants' rooms or in an adja- cent hall. With prolonted exposure to the presence of large numbers of Formosan termites, or to these fungi, it is possible for a person to become toxic by inhalation as naphthalene is quite volatile. Route -  Human exposure to naphthalene (NA), an acute lung toxicant and possible human carcinogen, is primarily through inhalation. Exposure to Naphthalene & Jaundice Symptom Checker: Possible causes include Naphthalene Poisoning. Naphthalene and paradichlorobenzene are two ingredients used in mothballs. Two-year Naphthalene Inhalation Study .. 7-17 Table 7-5. Inhal Toxicol 13:931-950. 91-20-3) in Sprague-Dawley Rats. But if managed properly, the patient can have a good outcome. Is the naphthalene that termites give off harmful to humans? Acute (short- term) exposure of humans to naphthalene by inhalation, ingestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. Naphthalene poisoning. Naphthalene poisoning occurs primarily as a result of accidental mothball ingestion, causing symptoms such as nausea, vomiting, hematuria and severe respiratory, neurologic and hepatic effects. Shopp, GM; White, KL, Jr.; Holsapple, MP; et al. 9-6 Table 9-2. f Exposure to Naphthalene may cause a skin allergy. Specialized studies have shown that continuous exposure to this product can cause severe abdominal pain, nausea, vomiting and diarrhea. While Naftalan crude oil is too heavy for normal export uses (unlike Azerbaijan's plentiful Caspian Sea oil), it contains about 50 percent naphthenic hydrocarbons.. The results of this study indicate that the LC 50 for naphthalene vapour in Wistar albino rats is greater than 77.7 ppm, (0.4 mg/L) naphthalene. Clinically, patients present with acute onset of dark brown urine, watery diarrhea, and non-bloody bilious vomiting 48-96 hours after exposure. Author: Flack-Walker, Faith A Created Date: REFERENCES *Abdo KM, Grumbein S, Chou BJ, et al. Naphthalene is a white solid substance with a strong smell. Naphthalene, a lung toxicant and possible human carcinogen, is a ubiquitous environmental pollutant with widespread human exposure. Incidence of Neoplasms in Male and Female F344/N Rats in a Two-year  Dose-Response Information from Five Key Studies of Naphthalene Toxicity . The characteristics of plasma discharge were studied by measuring voltage and current waveforms and the Lissajous figure. Naphthalene toxicity Handling naphthalene must be done with strict caution, as it is a very toxic substance. Immediately or shortly after exposure to a level of 15,000 ppbv of naphthalene in air, a persons eyes, nose or throat may feel irritated. Phone 13 11 26. Inhalation: On inhalation naphthalene cases headache, confusion, excitement, nausea, vomiting and sweating. persistent signs and symptoms. Breathing in the fumes over a period of time can cause poisoning, too. Exposure to naphthalene and its substituted analogs is predominantly through inhalation although the toxicity of these compounds does not generally require inhalation, that is, parenteral administration produces the same selective damage to lung tissues as inhalation (Mahvi et al., 1977; Tong et al., 1982). The U.S. Department of Energy's Office of Scientific and Technical Information Toxicity and carcinogenicity study in F344 rats following 2 years of whole-body exposure to naphthalene vapors. A 33-year-old Sri Lankan woman  Acute lung toxicity and carcinogenesis are thought to be related because the target sites for both are similar. Mothballs slowly turn from solids to toxic vapor. f High exposure to Naphthalene can cause headache, fatigue, confusion, tremor, nausea and vomiting. Toxicjaundice is notifiable. 1993. In the nose, naphthalene exposure was with associated an increage the in incidence and severity of chronic inflammation, metaplasia of the olfactory epithelium, and hyper- plasia of Background: The potential carcinogenicity of naphthalene (NA), a ubiquitous environmental pollutant, in human respiratory tract is a subject of intense debate. The chosen IDLH, therefore, has been estimated from the probable oral lethal dose of 5 to 15 grams for an adult [Gerarde 1960 cited by AIHA 1967]. Naphthalene can be absorbed by the oral, inhalation, and dermal routes of exposure and can cross the placenta in amounts sufficient to cause fetal toxicity. Naphthalene can also irritate the skin. There may be dysuria, haematuria and an acute haemolytic reaction. Most exposure occurs through low dose chronic inhalation, dermal contact or ingestion through the food chain. This article is for information only. Rare cases of mothball abuse predominantly by inhalation do occur. In Azerbaijan, people using the oil  The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. NAPHTHALENE, 1-METHYLNAPHTHALENE, AND 2-METHYLNAPHTHALENE 219 9. Naphthalene is a bicyclic aromatic compound that has wide industrial and commercial applications. In summary, naphthalene mothball ingestion can present with prolonged haemolytic anaemia and methaemoglobinaemia.  The poison repels their major enemy, ants, as well as microscopic worms, bacteria and fungus in the soil. Naphthalene poisoning is a rare form of toxicity that may occur after ingestion, inhalation, or dermal exposure to naphthalene-containing compounds such as mothballs. Background: Naphthalene is a polycyclic aromatic hydrocarbon that has been associated with health effects, including cancer. by Glossary. Recognizing Symptoms of Exposure to Naphthalene in Mothballs Mothballs can cause various health effects if the exposure is high enough.  Fundam Appl Toxicol 4(3 pt 1):406-419. Route - ingested, inhaled, topical exposure. Background: Naphthalene is a naturally occurring polycyclic aromatic hydrocarbon that is also manufactured for use in consumer products such as moth repellents and has been associated with a variety of health effects including cancer. A case of naphthalene toxicity in a 20-year-old autistic male, who improved with supportive care, red blood cell transfusion, and ascorbic acid and N-acetylcysteine is presented. We determined plasma, lung, and liver levels of naphthalene and naphthalene-glutathione conjugate, a biomarker of naphthalene bioactivation, over time after naphthalene inhalation. NAPHTHALENE, 1-METHYLNAPHTHALENE, AND 2-METHYLNAPHTHALENE 219 9. Most exposure occurs through low dose chronic inhalation, dermal contact or ingestion through the food chain. Naphthalene can be absorbed by the oral, inhalation, and dermal routes of exposure and can cross the placenta in amounts sufficient to cause fetal toxicity. The LD 50 is 1.8 g/kg in adult rats. In the nose, naphthalene exposure was with associated an increage the in incidence and severity of chronic inflammation, metaplasia of the olfactory epithelium, and hyper- plasia of Toilet bowl deodorizers also contain naphthalene. Clinically, patients present with acute onset of dark brown urine, watery diarrhea, and non-bloody bilious vomiting 48-96 hours after exposure. Talk to our Chatbot to narrow down your search. Answer (1 of 2): Termites use naphthalene to protect their nests. Abraham BM, Liu TY, Robert A, et al. 91-20-3) in Sprague-Dawley Rats. Naphthalene poisoning is a rare form of toxicity that may occur after ingestion, inhalation, or dermal exposure to naphthalene-containing compounds such as mothballs. Naphthalene is a white solid substance with a distinctive odor. It rarely occurs in suicidal attempts in adults and in accidental ingestion by children. It is also called white tar, and tar camphor, and has been used in mothballs and moth flakes. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. i. Toxicity and carcinogenicity study in F344 rats following 2 years of whole-body exposure to naphthalene vapors. National Population Estimates for Naphthalene Exposure via Drinking Water .. 9-11 Table 9-3. Acute hemolysis may occur, especially in patients with G6PD deficiency. Background: Naphthalene ingestion and skin or inhalational exposure (accidental or deliberate) is an under-recognized cause of a severe toxidrome in regions where it is commonly used (e.g., mothballs in households). Abstract. Drinker et al. A 2 year old boy who had accidentally consumed unknown number of moth balls presented 3 d later with vomiting, seizures, methemoglobinemia, hemolytic anemia and altered sensorium. repeated exposure can cause clouding of the eye lens (cataract), which may damage vision. The effects of different parameters of the process on naphthalene decomposition in air were investigated. Symptoms of acute exposure include headache, nausea, vomiting, diarrhea, malaise, confusion, anemia, jaundice, convulsions, and coma. Is it safe to use naphthalene balls? Toxicity rating: Slightly to Moderately Toxic Health Eects: Can cause cataracts and damage to the retina. It is an organic  Acute lung toxicity and carcinogenesis are thought to be related because the target sites for both are similar. Poison Center at 1-800-222-1222. The site is secure. Chapter 3: Health Effects: Specific health effects of a given hazardous compound are reported by type of health effect (death, systemic, immunologic, reproductive), by route of exposure, and by length of exposure (acute, intermediate, and chronic). Phone 13 11 26. f Inhaling Naphthalene can irritate the nose and throat causing coughing and wheezing. (1985) Naphthalene poisoning following ingestion of moth balls: Case report. If the nausea does not pass or the vomiting persists, seek medical attention. Toxicity to Animals: WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Naphthalene may also damage the liver, kidneys and the eyes. (1984) Naphthalene toxicity in CD-1 mice: general toxicology and immunotoxicology. Naphthalene-containing mothballs can cause methemoglobinemia on inhalation. Inhalation. Toxicity from naphthalene and paradichlorobenzene is most dangerous with ingestion, but documentation shows that inhalation of vapors and dermal exposure can cause serious effects and irritation to dogs as well. Enough absorption can occur by inhalation of naphthalene vapor to cause significant toxicity. After being exposed to naphthalene, be alert for the sudden onset of a headache. July 18, 2021. in N. 0. Very high levels of naphthalene can cause headaches and nausea. increase in severity with increasing exposure duration and most effects were observed within a shorter duration Critical effect(s): Decrease in terminal body weight  Developmental Toxicity of Naphthalene (CAS No. Eye contact. Chief among the uncertainties in risk assessment for NA is whether human lung CYP2A13 and CYP2F1 can mediate NAs respiratory tract toxicity. As little as 250500 mg may produce hemolysis in a patient with G6PD deficiency. The 77.7 ppm concentration was the highest naphthalene vapour concentration obtainable under the conditions of the study. Naphthalene moth ball poisoning in children can present with diagnostic and therapeutic challenges. The toxicity database for NAA is complete, except for a subchronic inhalation toxicity study. Ingestion, either accidental or by deliberate self-harm, can occur due to its abundance as well as its candy-resembling appearance. Naphthalene poisoning is a rare form of toxicity that may occur after ingestion, inhalation, or dermal exposure to naphthalene-containing compounds such as mothballs. EPA has also reviewed naphthalene toxicity for registration as a non-food use pesticide, and did not derive an inhalation unit risk (EPA, 2008). 2001. WEIGHT-OF-EVIDENCE CHARACTERIZATION: Using criteria of the 1986 Guidelines for Carcinogen Risk Assessment, naphthalene is classified in group C, a possible human carcinogen. Exposure to naphthalene and its substituted analogs is predominantly through inhalation although the toxicity of these compounds does not generally require inhalation, that is, parenteral administration produces the same selective damage to lung tissues as inhalation (Mahvi et al., 1977; Tong et al., 1982). Though it is freely available around this country, poisoning has never been reported in the literature. Naphthalene. Vital sign abnormalities include fever, tachycardia,  Groups of male and female albino CD-1 mice (approximately 6 weeks old at the start) were administered gavage doses of 0, 5.3, 53, or 133 mg/kg naphthalene (99.3% pure) in corn oil Californias Office  Naphthalene Inhalation and Cancer - Animal Studies The NTP has conducted naphthalene inhalation cancer  It can affect how blood carries oxygen to the heart, brain, and other organs. Exposure to large amounts of naphthalene may damage or destroy some red blood cells, causing a low level until the body replaces the destroyed cells. Accidental poisoning with naphthalene occurs much more commonly than is reported in biomedical literature . Fundam Appl Toxicol 4(3 pt 1):406-419. If swallowed, naphthalene can damage red blood cells, causing kidney damage and many other problems. One of these infants died. Naphthalene poisoning is an uncommon poisoning due to its pungent smell, taste, insolubility in water, and poor absorption from the gut. The U.S. Department of Energy's Office of Scientific and Technical Information  Ojwang, P.J., Ahmed-Jushuf, I.H. and Abdullah, M.S. Ingestion. This can indicate poisoning and should not be taken lightly. Human exposure to naphthalene (NA), an acute lung toxicant and possible human carcinogen, is primarily through inhalation. Toxicologists are available 24/7 to provide specific clinical advice, and require the following clinical information: Agent: (drug / substance, name and formulation - immediate or modified release) Beware of the possibility of mixed overdose. Chief among the uncertainties in risk assessment for NA is whether human lung CYP2A13 and CYP2F1 can mediate NAs respiratory tract toxicity. As little as 250500 mg may produce hemolysis in a patient with G6PD deficiency. In this study, coaxial dielectric barrier discharge (DBD) plasma, in conjunction with a metal oxide catalyst, was used to degrade naphthalene. As the state of the science on naphthalene toxicity continues to evolve, updated toxicity reference value(s) may be required to support human health risk assessment. (Hide) Abraham BM, Liu TY, Robert A, et al. In 1989 there were 2,300 reported ingestion of naphthalene ball by children under the age of 6 in United States alone . Human exposure to naphthalene (NA), an acute lung toxicant and possible human carcinogen, is primarily through inhalation. Toxicologists are available 24/7 to provide specific clinical advice, and require the following clinical information: Agent: (drug / substance, name and formulation - immediate or modified release) Beware of the possibility of mixed overdose. Short-term exposure guidelines: None developed. Shopp, GM; White, KL, Jr.; Holsapple, MP; et al. Naphthalene has caused cancer in animals. Fuels such as petroleum and coal contain naphthalene. ACUTE TOXICITY DATA: It is best known as the main ingredient of  Naftalan or Naphtalan is a type of crude oil.It is named after Naftalan, Azerbaijan, where it is found.It is known for its high naphthalene content and use in alternative medicine.. and assesses the significance of toxicity data to human health. f Inhaling Naphthalene can irritate the nose and throat. Acute oral and subchronic inhalation exposure of humans to naphthalene has resulted in neurotoxic effects (confusion, lethargy, listlessness, vertigo), gastrointestinal distress, hepatic effects (jaundice, hepatomegaly, elevated serum enzyme levels), renal effects, and ocular effects (cataracts, optical atrophy). Chronic (long-term) exposure of workers and rodents to naphthalene has been reported to cause cataracts and damage to the retina. Exposure to large amounts of naphthalene may also cause nausea, vomiting, diarrhea and blood in the urine. Inhal Toxicol 13:931-950. It is used as the starting material for the synthesis of other compounds, as a moth repellent, soil fumigant and lavatory deodorant. Naphthalene poisoning. What mothers-to-be inhale, so does baby so the developing bodies of unborn children are especially susceptible to naphthalene poisoning. Use of naphthalene in the domestic environment is associated with the risk of toxicity due to inhalation and ingestion, notably in children. Acute lung toxicity and carcinogenesis are thought to be related because the target sites for both are similar. An upset stomach and vomiting can both be symptoms of moth ball inhalation. Naphthalene (mothball) is a commonly used deodorizer in the Indian subcontinent, including Sri Lanka. (1937) consider that the inhalation of the fumes from these processes is the mode of absorp-tion in the cases with hepatic damage. DO NOT use it to treat or manage an actual poison exposure. Naphthalene is a white solid that evaporates easily. 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